LRRK2 - related reading

Given the success of the previous LRRK2 focused meetings, the Biochemical Society will be holding its next Biennial International LRRK2 Meeting on 13-16 April 2021 in France. The articles below have been curated by our publisher, Portland Press, and explores some of the latest biochemical, cellular and translational LRRK2 research in regards to future clinical applications.

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
Evy Lobbestael; Chris Van den Haute; Francesca Macchi; Jean-Marc Taymans; Veerle Baekelandt
Biosci Rep (2020) 40 (10): BSR20202225.

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72
Sophie Vieweg; Katie Mulholland; Bastian Bräuning; Nitin Kachariya; Yu-Chiang Lai; Rachel Toth; Pawan Kishor Singh; Ilaria Volpi; Michael Sattler; Michael Groll; Aymelt Itzen; Miratul M. K. Muqit 
Biochem J (2020) 477 (9): 1651–1668.

Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies
Rebecca L. Wallings; Malú G. Tansey 
Biochem Soc Trans (2019) 47 (6): 1581–1595.

LRRK2 regulation of immune-pathways and inflammatory disease
Rebecca L. Wallings; Malú G. Tansey
Biochem Soc Trans (2019) 47 (6): 1581–1595.

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson’s disease patients
Belén Fernández; Antonio Jesús Lara Ordóñez; Elena Fdez; Eugénie Mutez; Thomas Comptdaer; Coline Leghay; Alexandre Kreisler; Clémence Simonin; Laurine Vandewynckel; Luc Defebvre; Alain Destée; Séverine Bleuse; Jean-Marc Taymans; Marie-Christine Chartier-Harlin; Sabine Hilfiker
Biochem J (2019) 476 (19): 2797–2813.

Autophagy in the mammalian nervous system: a primer for neuroscientists
Fumi Suomi; Thomas G. McWilliams 
Neuronal Signal (2019) 3 (3): NS20180134.

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
Tiago Fleming Outeiro; Kirsten Harvey; Antonio Dominguez-Meijide; Ellen Gerhardt
Biochem Soc Trans (2019) 47 (3): 827–838.

LRRK2 links genetic and sporadic Parkinson’s disease
Jillian H. Kluss; Adamantios Mamais; Mark R. Cookson 
Biochem Soc Trans (2019) 47 (2): 651–661.

Caught in the act: LRRK2 in exosomes
Shijie Wang; Andrew B. West 
Biochem Soc Trans (2019) 47 (2): 663–670.

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes
Emmanouela Leandrou; Eliana Markidi; Anna Memou; Katerina Melachroinou; Elisa Greggio; Hardy J. Rideout 
Biochem J (2019) 476 (3): 559–579.

The role of LRRK2 in cell signalling
Kirsten Harvey; Tiago F. Outeiro
Biochem Soc Trans (2019) 47 (1): 197–207.

Mitochondrial quality control and neurodegenerative disease
Fei Gao; Jianmin Zhang
Neuronal Signal (2018) 2 (4): NS20180062.

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Biennial International LRRK2 Meeting 2021