Whilst previous works have shown that some rRNA modification types can be dynamically regulated, the mammalian rRNA modification landscape remains largely unexplored.

Aiming to address this, a recent paper by Milenkovic et al., employed direct RNA sequencing to chart the human and mouse rRNA epitranscriptome across tissues, developmental stages, cell types, and disease. In this webinar, Ivan Milenkovic presented their findings and discussed how epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures.

Invited Speaker:

• Ivan Milenkovic, Centre for Genomic Regulation, Spain

This webinar was chaired by Professor Claire Shovlin, Imperial College London, UK.