Translation UK 2017

Translation, the process of making proteins encoded by the genome, is a fundamental process of life. It is highly conserved and exquisitely regulated. The regulation of translation plays a key role in many biological processes, including early development, cell proliferation, metabolic regulation, viral infection and the response to stress. Research on translation contributes to both fundamental understanding of biological processes, as well as to applications such as drug development, agriculture and biotechnology.

The Translation UK meetings always have a wide ranging coverage of the field, from ribosome structure to translational control of gene expression. Presented work varies from studies of single gene/mRNA to genome wide investigations, using systems from bacteria to human cells. We included a session to highlight the exciting recent developments in covalent mRNA modification, also known as epitranscriptomics, and translation. We actively invited researchers working on epitranscriptomics as well as the regular Translation UK community.

Translation UK has served as the focus of a large UK research community for more than 20 years, and is attended by world-leading researchers from the UK and overseas. Its annual occurrence strengthens the UK research community by providing important networking opportunities and disseminating the latest research to a wide audience. The meetings have been particularly successful in in developing the careers of junior scientists, providing opportunities for them to interact with leaders in the field as well as their peers in both formal and informal settings. Numerous PhD students have had their first conference experience at Translation UK and some are now amongst the leaders of the field themselves.


Rupert Fray (University of Nottingham, United Kingdom)
Cornelia De Moor (The University of Nottingham, United Kingdom)
Anna Piccinini (University of Nottingham, United Kingdom)
Keith Spriggs (University of Nottingham, United Kingdom)
Sebastiaan Winkler (University of Nottingham, United Kingdom)
Catherine Jopling (University of Nottingham, United Kingdom)
Thursday 6 July 2017
11:30 – 13:00 Registration and Lunch


Session 1: RNA modification and regulatory mechanisms

Thursday 6 July 2017
13:00 – 13:15
Meeting Introduction
13:15 – 14:00
The role of RNA methylation in translational control
Samie Jaffrey (Cornell University, U.S.A.)
14:00 – 14:15
Identification of Factors Required for m6A mRNA Methylation in Arabidopsis Reveals a Role for the Conserved E3 Ubiquitin Ligase HAKAI
Rupert Fray (University of Nottingham, United Kingdom)
14:15 – 14:30
P-bodies are involved in coordinated translational repression but not in mRNA decay
Dominique Weil (Institut de Biologie Paris-Seine – University Pierre et Marie Curie, France)
14:30 – 14:45
Dual RNA processing roles of Pat1b via cytoplasmic Lsm1-7 and nuclear Lsm2-8 complexes
Nancy Standart (University of Cambridge, United Kingdom)
14:45 – 15:00
Translation of circular RNAs in eukaryotes
Gaia Di Timoteo (Sapienza University of Rome, Italy)
15:00 – 15:30 Refreshment Break


Session 2: Initiation factors and signalling

Thursday 6 July 2017
15:30 – 15:45
Identification of transcripts that are differentially translated upon phosphorylation of translation factor eIF2 in erythroblasts
Nahuel Paolini (Sanquin Research, The Netherlands)
15:45 – 16:00
eIF2B regulation and localisation in yeast as a response to quorum sensing alcohols
Tawni O Dornelles (University of Manchester, United Kingdom)
16:00 – 16:15
The mTOR-S6 Kinase Pathway Regulates the Formation and Function of Stress Granules
Aristeidis Sfakianos (University of Manchester, United Kingdom)
16:15 – 16:30
mTOR-eIF2 cross-talk signalling in response to DNA damage
Robert Harvey (MRC Toxicology Unit, United Kingdom)
16:30 – 16:45
Differential requirement for eIF4G isoforms in oxidative stress resistance and metabolism
Paraskevi Kritsiligkou (University of Manchester, United Kingdom)
16:45 – 17:00
eIF4E phosphorylation and the MNKs are critical for KRAS-driven intestinal tumorigenesis and can be targeted in vivo
John Knight (CRUK Beatson Institute, United Kigdom)
17:00 – 17:15
Structural and mechanistic insights into how DHX29 promotes scanning
Trevor Sweeney (University of Cambridge, United Kingdom)
17:15 – 17:30 Flash Poster Presentations

17:30 – 19:00 Poster Session 1

19:30 Conference Dinner


Session 3: Disease and development

Friday 7 July 2017
09:00 – 09:45
Translational control in cancer
Fatima Gebauer (Centre for Genomic Regulation, Spain)
09:45 – 10:00
Cisplatin induces the rearrangement of RBPs on CDKN1B/p27 mRNAs
Valentina Iadevaia (University of Surrey, United Kingdom)
10:00 – 10:15
Coupling of mRNA translation with mitochondrial functions in cancer cells by TRAP1 chaperone
Danilo Swann Matassa (University of Naples Federico II, Italy)
10:15 – 10:30
Role of the novel endoribonuclease SLFN14 and its disease causing mutations in ribosomal degradation
Neil Morgan (University of Birmingham, United Kingdom)
10:30 – 11:00 Refreshment Break

11:00 – 11:15
The cell-cycle regulator RGC-32 is a critical regulator of B-cell growth and is translationally controlled by Pumilio
Sarika Khasnis (University of Sussex, United Kingdom)
11:15 – 11:30
GRASPS: A novel translatome technology to identify functional consequences of widespread RNA dysregulation in neurodegeneration
Ya-hui Lin (Sheffield University, United Kingdom)
11:30 – 11:45
Control of pituitary cell plasticity through regulated mRNA translation
Angus MacNicol (University of Arkansas for Medical Sciences, U.S.A.)
11:45 – 12:00
Ribosome-mediated effects on Drosophila embryonic patterning
Andrew Renault (University of Nottingham, United Kingdom)
12:00 – 12:15
Role of axonal miRNAs -26a and -99a in cortical neuron polarization and axonal growth: implications for neuron connectivity and Alzheimer’s disease pathology
Federico Dajas-Bailador (University of Nottingham, United Kingdom)
12:15 – 12:30 Flash Poster Presentations

12:30 – 14:00 Lunch and Poster Session 2


Session 4: Translational control mechanisms

Friday 7 July 2017
14:00 – 14:15
G-quadruplex mediated control of translation initiation depends upon local structural context
Joseph Waldron (MRC Toxicology Unit, United Kingdom)
14:15 – 14:30
Investigation into the role and mechanism of leaderless translation in mycobacteria
Beth Sawyer (London School of Hygiene & Tropical Medicine, United Kingdom)
14:30 – 14:45
Developing novel reporters for studying peptides involve eukaryotic translational recoding
Man Balola Jr. (Newcastle University, United Kingdom)
14:45 – 15:00
Identifying RNA-binding protein changes upon mTORC1/2 inactivation using interactome capture
Ewan Smith (MRC Toxicology Unit, United Kingdom)
15:00 – 15:15
Translation initiation events on structured eukaryotic mRNAs generate gene expression noise
Estelle Dacheux (University of Warwick, United Kingdom)
15:15 – 15:30
The translational response to amino acid starvation in S. Pombe
Caia Duncan (University of Cambridge, United Kingdom)
15:30 – 15:45 Concluding remarks and meeting close


Jul 06 2017 - Jul 07 2017


All Day
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