Non-Coding RNA: Recent Insights into the Mechanisms of Action 2017

One of the research areas expected to impact most of the understanding gene regulation in the next few years is discovering how ncRNAs influence the regulation of cellular pathways.


With recent exciting discoveries being made around the biological scope and mechanisms of actions for ncRNA molecules which impacts research into development and disease, this meeting couldn’t be more timely.


Synthesising state-of-the-art insights that span across next-generation sequencing, functional genomics and ncRNA manipulation, this meeting aimed to broaden your understanding of the mechanisms behind ncRNA’s regulation of cellular pathways. We discussed the analyses of transcriptomic data, experiments for linking ncRNAs sequences and structure to functions, whilst addressing approaches to bridge the gap between the large number of ncRNAs identified in various species, and the lack of well-defined functions for ncRNAs.


We invited scientists to submit an abstract and register who have common interests in ncRNA biology with topics spanning from functional discoveries of ncRNA to the novel techniques used to uncover ncRNA function) including the role ncRNA in disease, in order to create a meeting that provided a forum to integrate novel findings, enhance previously proposed models of ncRNA function and generate new testable and publishable hypotheses.

Andrea Caporali (University of Edinburgh, UK)
Andrew Baker (University of Edinburgh, UK)
Donal O’Carroll (University of Edinburgh, UK)
Javier Caceres (University of Edinburgh, UK)
Thursday 22 June 2017
12:00 – 13:00 Registration


Session 1: ncRNA and epigenetic regulation

Thursday 22 June 2017
13:00 – 13:30
GxE in worm and fish
Eric Miska (Gurdon Institute, University of Cambridge, United Kingdom)
13:30 – 14:00
Expression and function of lncRNAs during oocyte-to-embryo transition
Petr Svoboda (IMG, Czech Republic)
14:00 – 14:30
Selected Oral Communication- Fitness landscape of a yeast snoRNA
Grzegorz Kudla (University of Edinburgh, UK)
14:30 – 15:00
Selected Oral Communication- Control of cell division by long noncoding RNAs
Lovorka Stojic (CRUK Cambridge Institute, UK)
15:00 – 15:30 Refreshment Break


Session 2: RNA decay

Thursday 22 June 2017
15:30 – 16:00
Tudor-SN-mediated endonucleolytic decay of human-cell microRNAs promotes G1/S phase transition
Lynne Maquat (University of Rochester, U.S.A.)
16:00 – 16:30
Uridylation-mediated cytoplasmic RNA quality control in mammalian cells
Stepanka Vanacova (CEITEC, Czech Republic)
16:30 – 17:00
Selected Oral Communication- Coordination of non-coding and messenger RNA lifecycles is essential for mammalian immune responses
Dimitris Lagos (University of York, UK)
17:00 – 17:30
Selected Oral Communication- TRBP and PACT pose stoichiometric questions for Dicer complex assembly
Michael Plevin (University of York, UK)
17:30 – 19:30 Drinks Reception and Informal Poster Viewing


Session 3: ncRNA and gene regulation

Friday 23 June 2017
09:00 – 09:30
What do mouse piRNAs do?
Phillip Zamore (University of Massachusetts Medical School, U.S.A.)
09:30 – 10:00
Irene Bozzoni (Sapienza University of Rome, Italy)
10:00 – 10:30
Selected Oral Communication- Interplay between a transcriptional coactivator – Psip1 and a lncRNA Hottip in regulation of Hox genes
Pradeepa Madapura (University of Essex, UK)
10:30 – 11:00
Selected Oral Communication- A cryptic RNA binding domain explains selectivity in Syncrip-mediated exosomal loading of miRNAs
Andres Ramos (University College London, UK)
11:00 – 11:30 Refreshment Break


Session 4: ncRNA in stem cells

Friday 23 June 2017
11:30 – 12:00
ncRNA biogenesis and quality control – links to disease
Richard Gregory (Harvard Medical School, U.S.A.)
12:00 – 12:30
Modes of action of long noncoding RNAs in mammalian cells
Igor Ulitsky (Weizmann Institute of Science, Israel)
12:30 – 13:00
RNA silencing using Antisense LNATM GapmeRs
Johnathan Lai (Exiqon, Denmark)
13:00 – 13:30
Selected Oral Communication- LIMD1 family proteins dictate a hierarchy of human Argonaute function
Kunal Shah (Queen Mary University London, UK)
13:30 – 14:30 Meet-the-expert lunch


Session 5: ncRNA in development and differentiation

Friday 23 June 2017
14:30 – 15:00
Function of cytosine-5 methyation in non-coding RNA
Michaela Frye (University of Cambridge, United Kingdom)
15:00 – 15:30
Dissecting the In Vivo Functions & Mechanisms of Action of lncRNAs
Alena Shkumatava (Institute Curie, France)
15:30 – 16:00
Selected Oral Communication -Long non-coding RNA SMILR interacts with Staufen1 regulatory protein and modulates cell cycle and histone associated mRNA networks.
Margaret Ballantyne (University of Edinburgh, UK)
16:00 – 16:30
Selected Oral Communication- Functional high-throughput screening identifies microRNA-26b as pro-survival and angiogeneic factor for endothelial cells
David Mellis (University of Edinburgh, UK)
16:30 – 17:00 Closing Remarks


Jun 22 2017 - Jun 23 2017


All Day
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