New Horizons in ESCRT Biology
A Biochemical Society Scientific Meeting
The Endosomal Sorting Complex Required for Transport (ESCRT) machinery is an essential membrane-remodelling complex that is conserved throughout evolution as far back as archaea. Since their discovery in 2001 as regulators of cargo sorting to the yeast vacuole, work on the ESCRT machinery has exploded as our understanding of this machinery’s role in remodelling different membranes has grown.
In addition to their classical role in endosomal sorting, this machinery is co-opted to perform similar membrane-remodelling events allowing HIV-1 release, release of exosomes and microvesicles, membrane abscission during cytokinesis, neuronal pruning, repair of damaged regions of plasma membrane and regeneration and repair of the nuclear envelope.
Given the explosion of ESCRT-biology, many researchers are new to the field and benefited from this meeting’s speakers, who comprised some of the leading active researchers who have been part of the wealth of exciting new discoveries in ESCRT research in recent years.
Topics covered included:
- ESCRTs in cell division – cytokinesis and nuclear envelope remodelling
- Viral exploitation of the ESCRT-machinery
- Biochemical assembly of ESCRTs
- Cargo sorting to the MVB
- Membrane Trafficking
- Emerging ESCRT functions
Topics covered in this meeting were invited to submit to our journal, Biochemical Society Transactions, or other publication published by Portland Press, the wholly-owned trading subsidiary of the Biochemical Society.