New Approaches for Investigating Nascent Peptide Folding
| This timely meeting investigated new methodologies for studying the early folding profiles of nascent proteins as they are being synthesised by ribosomes.
With growing evidence, supported by several high impact publications in the last few months, that the vast majority of proteins fold into their native structures before they are released by the ribosome, this meeting aimed to discuss protein folding and how it is inherently coupled to protein synthesis and chain elongation. The efficiency of these folding and targeting mechanisms is imperative to the smooth running of cellular processes.
With an introductory talk discussing how high resolution structures of the ribosome have revealed exciting information about the molecular basis of protein synthesis, given by Nobel Laureate and President of the Royal Society, Professor Venki Ramakrishnan, this was an excellent opportunity to network and meet to discuss research. |
Monday 11 December
| 13:30 – 14:00 | (S001) Silent polymorphic mutations (sSNP) speak out: alterations of protein function and folding by sSNPs – , |
| 14:00 – 14:30 | Translation Rate and Protein Fate – , |
| 14:30 – 14:50 | (OC006) The ribosome restrains molten globule formation in stalled nascent flavodoxin – , |
| 14:50 – 15:10 | (OC004) Kinetic and structural comparison of the co-translational and refolding pathways of HaloTag – , |
| 15:40 – 16:10 | (S002) Co-translational folding of alpha helical membrane proteins in lipid bilayers – , |
| 16:10 – 16:30 | (OC002) Disulfide formation during nascent polypeptide folding – , |
Tuesday 12 December
| 11:30 – 12:00 | (S004) Cotranslational protein folding – , |
| 12:00 – 12:30 | Principles of Protein Structural Ensemble Determination – , |
| 12:30 – 13:00 | Kinetics of peptide and protein aggregation – , |
| 14:00 – 14:30 | (S005) Regulation of Human Translation Termination by Factors bound to the mRNA 3’Untranslated Region – , |
| 14:30 – 15:00 | (S006) Structural studies of protein folding on the ribosome – , |
| 15:00 – 15:20 | (OC001) The translating human mitochondrial ribosome in action – snapshots observed by cryo-EM – , |
| 16:00 – 17:00 | (S007) The exit tunnel in mitochondrial ribosomes – , |
Wednesday 13 December
| 09:10 – 09:40 | (S008) Interaction of the N-acetyl transferase NatA with the ribosome – , |
| 09:40 – 10:10 | (S009) Co-translational interactions of nascent chains revealed by ribosome profiling – , |
| 10:10 – 10:30 | (OC003) Dual function of the ribosome and the trigger factor chaperone in nascent protein folding – , |
| 11:00 – 11:30 | (S010) Real-Time Folding of Proteins Emerging From the Ribosome – , |
| 11:30 – 12:00 | (S011) Antibiotics and peptides in the ribosomal exit tunnel – , |
