Metabolic consequences of molecular signalling in muscle during and after exercise
by Professor Erik A. Richter, 2021 Sir Philip Randle Award winner
Time: 14:00 – 15:00 GMT
At this webinar we will hear from the 2021 Sir Philip Randle Award winner, Professor Erik A. Richter at the University of Copenhagen, Denmark.
Exercise is a catabolic event and therefore requires mobilization of fuels and oxidation of these fuels in the working muscles. This requires a plethora of molecular signalling in muscles as well as a specific neuro-endocrine stress-response. This includes neuro-endocrine activity that activates lipolysis in adipose tissue and increase hepatic glucose production to avoid a decrease in plasma glucose due to increased glucose uptake by muscle. Different modes of exercise induce different but overlapping neuro-endocrine secretion as well as different molecular signalling in muscle. Our knowledge of this molecular signalling in skeletal muscle during exercise has exploded due to various novel proteomic techniques. Much of this signalling has no known function and therefore the challenge is now to figure out the functional consequences of this myriad of signalling. In contrast to the catabolic conditions during exercise, the post-exercise condition is anabolic with priority given to refilling of muscle glycogen stores. This is facilitated by the post-exercise increase in muscle insulin action, which is due to a coordinated increase in insulin-induced microvascular perfusion and molecular signalling. During his Award lecture, Professor Richter will discuss these different aspects of exercise.
- 2021 Sir Philip Randle Award winner, Professor Erik A. Richter at the University of Copenhagen, Denmark
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