Insulin and exercise signalling for glucose homeostasis and metabolic health

A Biochemical Society Focused Meeting

It has become very evident that there are multiple-levels of interaction between the insulin signalling pathway leading to stimulation of glucose transport in insulin-target tissues and the signalling events that occur downstream of exercise and dietary inputs.

The aim of this timely meeting was to generate valuable discussion focused on the multiple pathways leading to stimulation of glucose transport in insulin-target tissues and address the mechanistic biochemical basis for these interactions.

In addition to talks from academic researchers and the nutrition and pharmaceutical industries, the meeting also included the 2017 Sir Philip Randle Lecture, awarded to Geoffrey D. Holman, University of Bath, UK, all of which allowed us to show how recent advances in this area of research can lead to new approaches for developing therapies in insulin resistance and associated health problems including obesity, heart disease and increased susceptibility to dementia.

Francoise Koumanov (University of Bath)
Kei Sakamoto (Nestlé Institute of Health Sciences SA)
Javier Gonzalez (University of Bath)
Dylan Thompson (University of Bath)
Wednesday 6 September 2017
12:30 – 13:30 Registration

13:30 – 13:40 Welcome note from the organisers


Session1: Exercise signalling to glucose homeostasis

Wednesday 6 September 2017
13:40 – 14:20
Integrative physiology of muscle glucose metabolism during and after exercise
Keynote speaker: Erik Richter (University of Copenhagen, Denmark)
14:20 – 15:00
Liver glycogen metabolism during and after prolonged exercise
Javier Gonzalez (University of Bath, United Kingdom)
15:00 – 15:40
Transcriptional changes associated with the skeletal muscle metabolic response to exercise in young and old humans
Francis Stephens (University of Exeter, United Kingdom)
15:40 – 16:00 Refreshment Break

16:00 – 16:20
The role of FXYD1 protein in energy metabolism
Selected Oral Communication – Alexander Chibalin (Karolinska Institutet, Sweden)
16:20 – 16:40
Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients
Selected Oral Communication – Kenneth Verboven (Hasselt University, Belgium)
16:40 – 17:00
Intramuscular triglycerides and perilipin proteins show fibre type specific increases in human skeletal muscle following 7 days high-fat, high-calorie diet.
Selected Oral Communication- Katie Whytock (Liverpool John Moores University, UK)
17:00 – 17:20
Skeletal muscle metabolic gene expression responses when food is consumed before or after morning exercise in obese or overweight/centrally obese men.
Selected Oral Communication – Gareth Wallis (University of Birmingham, UK)
17:20 – 19:00 Poster Session 1 Sponsored by Nestlé Institute of Health Sciences SA

19:00 Evening networking opportunities: Healthy living Skyline walk to Sham castle to admire the view over Bath

Thursday 7 September 2017
09:00 – 09:10
Samuel W. Cushman (The Diabetes, Endocrinology, and Obesity Branch, The National Institutes of Health, U.S.A.)
09:10 – 09:50
Randle lecture 2017
Chemical biology probes of mammalian GLUT structure and function
Geoffrey Holman (University of Bath, United Kingdom)
09:50 – 10:10 Refreshment break


Session 2: Cell biology of glucose transport

Thursday 7 September 2017
10:10 – 10:50
Influence of the CHC22 clathrin isoform on human glucose metabolism
Frances Brodsky (University College London, United Kingdom)
10:50 – 11:30
The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the insulin-responsive glucose transporter GLUT4 in adipocytes
Nia Bryant (University of York, United Kingdom)
11:30 – 12:10
Golgins: coiled-coil vesicle tethers that capture transport carriers arriving at the Golgi from different destinations
Alison Gillingham (University of Cambridge, United Kingdom)
12:10 – 12:30
The Distillation Hypothesis: Why is Glut4 Trafficking so Complicated?
Selected Oral Communication- Cynthia Mastick (University of Nevada School of Medicine, USA)
12:30 – 12:50
The Role of Sortilin in Recycling of Glut4
Selected Oral Communication – Konstantin Kandror (Boston University School of Medicine, USA)
12:50 – 14:20 Lunch and Poster Session 2


Session 3: Signalling links to GLUT4 traffic

Thursday 7 September 2017
14:20 – 15:00
GAPs in insulin action and exercise
Hadi Al-Hasani (German Diabetes Center, Germany)
15:00 – 15:40
Investigating the interactome of TBC1D1 and its regulation by AMPK activators and a naturally occuring R125W mutation in the TBC1D1 phosphotyrosine binding domain
Jeremy Tavare (University of Bristol, United Kingdom)
15:40 – 16:00
α1A-Adrenoceptors promote glucose uptake and cell growth by activating mTOR
Selected Oral Communication – Saori Mukaida (University of Nottingham, UK)
16:00 – 16:20
Rab GAPs AS160 and Tbc1d1 play distinct roles in the regulation of glucose, lipid, and energy homeostasis
Selected Oral Communication – Susanna R. Keller (University of Virginia, USA)
16:20 – 16:40 Refreshment Break

16:40 – 17:20
Phosphorylation of SNARE proteins in the control of Glut4 trafficking
Gwyn Gould (University of Glasgow, United Kingdom)
17:20 – 18:00
Effects of modestly reduced insulin secretion in insulin sensitivity and lifespan/ A vision for an academic-industry hybrid institute dedicated to type 2 diabetes discovery research
James D. Johnson (Novo Nordisk Research Centre Oxford, UK)
18:00 – 18:20
Human Adipose Cells in vitro Are Either Refractory or Responsive to Insulin, Reflecting Host Metabolic State
Samuel W. Cushman (The Diabetes, Endocrinology, and Obesity Branch, The National Institutes of Health, U.S.A.)
18:20 – 18:40
Understanding the adiponectin receptors AdipoR1 and AdipoR2 – atypical modulators of insulin and exercise signalling networks and glucose homeostasis
Selected oral presentation – Jon Whitehead (University of Lincoln, UK)
18:40 – 19:00
Imprinted Grb10 in early life programming of life-long health.
Selected Oral Communication – Kim Moorwood (University of Bath, UK)
19:30 Conference dinner in the Pump room at the heart of the historic city of Bath


Session 4: Glucose homeostatic control of metabolic health (obesity/insulin resistance)

Friday 8 September 2017
09:00 – 09:40
Genetic and epigenetic alterations contributing to obesity and insulin resistance
Annette Schürmann (German Institute of Human Nutrition, Germany, Sponsored by The Nutrition Society)
09:40 – 10:20
Targeting 5-HT circuits to improve obesity and insulin resistance
Lora Heisler (Rowett Institute of Nutrition and Health, United Kingdom)
10:20 – 11:00
Exploring the role of adipose inflammation in insulin resistance – human insights.
David Savage (University of Cambridge, United Kingdom)
11:00 – 11:30 Refreshment Break

11:30 – 12:10
miRNAs regulating skeletal muscle metabolism
Anna Krook (Karolinska Institutet, Sweden)
12:10 – 12:50
AMP-dependent/AMPK-independent control of glucose homeostasis
Kei Sakamoto (Nestle Institute of Health Sciences SA, Switzerland)
12:50 – 13:00 Concluding remarks


Sep 06 2017 - Aug 08 2019


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