The application of styrene-maleic acid (SMA) co-polymers to extract small discs of membrane, termed SMA lipid particles (SMALPs), has changed the established landscape of research in biological membranes. Membrane proteins play a vital role in cellular communication and the control of transport across the membrane, making them key therapeutic targets for many human diseases. Their location within the membrane, tightly packed with so many different proteins and lipids has, until now, made them extremely challenging to study. By allowing membrane proteins to be purified and studied whilst maintaining their lipid environment, the SMALP methodology enables the study of membrane protein structure and function using techniques that were previously impractical.
New applications of SMALPs are rapidly emerging making membrane protein study more accessible and widespread. This meeting will explore the latest developments within the field, including novel polymers, techniques and targets, bringing together a wide range of researchers to share their findings.
03 May - 07 May
All of the day
FEBS3+ Meeting: 86th Harden Conference – Machines on Genes
From bacteria to eukaryotes, cells have evolved a remarkable battery of enzymes to deal with the mechanical and topological challenges presented by nucleic acid production, processing and maintenance. A clear view of the biology of the genetic material requires a molecular understanding of how these enzymes function. Such an understanding will enhance our ability to manipulate genome structure and gene expression.
The theme of this meeting revolves around the mechanisms of these enzymes, with particular emphasis on research that integrates structural, biochemical, biophysical and computational approaches. With recent technological advances in imaging (i.e., single-molecule and cryo-electron microscopies), we expect to witness a flourish of key biological systems to be characterised with unprecedented detail.
The meeting will cover many of the molecular mechanisms by which large macromolecular machines carry out a diverse range of nucleic acid processes including DNA replication and repair, gene transcription and regulation, RNA processing and splicing, translation, nucleic acids structures and chromatin structure and epigenetic mechanisms. The meeting will also explore new quantitative techniques as well as theoretical approaches.
Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease, responsible for up to 2-3% of all cases in the UK and up to 40% in some populations. Coupled with its clear genetic links to PD, LRRK2’s status as a complex, multi-domain kinase has led to this protein being flagged as one of the most promising drug targets for Parkinson’s disease.
This is a field that is exponentially attracting the interest of a considerable number of internationally competitive investigators, both from academia and the pharmaceutical industry, witnessing major advances in our understanding of the function of LRRK2 and its role in human disease.
06 July - 09 July
All of the day
Small G proteins in cellular signalling and disease
Small G proteins of the Ras superfamily regulate a plethora of cell signalling pathways and impact on most biological processes. Deregulation of these proteins and their pathways often results in disease, such as cancer and genetic disorders, and plays a role in infection by pathogenic organisms.
This conference will gather renowned experts to discuss research covering all five families of small G proteins, to highlight recent advances in understanding the molecular mechanisms of small G protein function, and to generate new ideas, collaborations and scientific strategies from diverse inputs. This will include the Ras family, involved in cell growth, the Rho family, which drive cytoskeletal rearrangements, the Arf and Rab families, which play a role in vesicle trafficking and Ran, which is responsible for nuclear transport.
Without a template, the biosynthesis of glycans heavily relies on the organisation of enzymes in the Golgi apparatus. In addition, glycan functions often feedback on important basic cell biological processes such as membrane trafficking and signalling. Therefore, understanding the interfaces between intracellular organisation and glycobiology is crucial to provide new tools and understanding for the functional investigation of glycans.
This scientific meeting will bring together glycoscientists with cell biologists to foster new ideas and collaborations between both disciplines. A range of topics from traditional cell and glycobiology through analytics and synthetic carbohydrate chemistry all the way to systems level studies will be explored at the event to encourage more joined-up thinking.
05 October - 06 October
All of the day
Low molecular weight thiols: lessons learned and new perspectives
Thiol redox reactions are implicated in a diverse range of physiological processes and are often dysregulated in human pathologies such as cancer, neurodegeneration and metabolic disorders. Low-molecular-weight (LMW) thiols play an essential role in maintaining the cellular redox homeostasis and exert important functions in cell growth, metabolism and detoxification pathways.
In the last decade, there have been significant advances in our understanding of redox biology, facilitated by the development of cutting-edge omics technologies and specific research tools. This conference will be one of the first to focus on the versatile family of LMW thiols, which comprises structurally diverse and evolutionarily unrelated molecules.
The programme will give attendees the chance to learn about the most recent advances on the role of LMW thiols in redox regulation and signalling from leading experts in the field, and networking opportunities will encourage new collaborative interactions between participants.